If driving to Bethany's main campus from either east or west, take Interstate 70 to Richmond, Indiana. Exit on Williamsburg Pike [exit 149]. Follow the pike as it turns into Fifth Street. At the intersection with National Road [US Route 40], turn right. Pass College Avenue on the left, then turn into the second driveway on the left. This is the Bethany Center's semi-circular drive with visitor parking.

The Dayton [Ohio] International Airport - 40 miles to the east - is the regional airport closest to Bethany's main campus.